149的生产:专注于产量和质量改善,朝着临床前应用的方向发展
C Favaretto1,2, P V Grundler2, Z Talip2
1Nuclear Medicine Department, University Hospital Basel, Basel, Switzerland.
Scientific reports
|February 9, 2024
概括
-149,一个有前途的放射性核化物用于向的α疗法,已成功生产和净化. 它的放射性标记与DOTATATE和临床前成像显示了潜在的治疗应用的高质量.
科学领域:
- 核医学就是核医学.
- 放射化学 放射化学是指辐射化学.
- 医学物理 医学物理
背景情况:
- 149 (Tb-149) 是针对性阿尔法疗法的潜在放射性核化物,因为它具有衰变特性.
- 尽量减少对健康组织的毒性对于有效的α粒子发射器至关重要.
- 生产和净化方法是使临床应用成为可能的关键.
研究的目的:
- 为了生产和净化Terbium-149用于向的α疗法.
- 用DOTATATE评估Tb-149的放射性标记效率.
- 为了评估Tb-149标记DOTATATE在体内临床前的疗效.
主要方法:
- 在CERN-ISOLDE,通过对进行质子辐射而产生的-149.
- 使用阴子交换和提取色谱进行质量分离和放射化学处理.
- 使用DOTATATE进行放射性标记和通过ICP-MS和PET/CT成像进行纯度评估.
主要成果:
- 获得的特-149具有>99%的放射性核素纯度和高特异活性.
- 通过DOTATATE放射性标记,达到99%以上的放射性化学纯度和50 MBq/nmol的摩尔活性.
- 在小鼠中成功的体内PET/CT成像显示出良好的瘤吸收.
结论:
- 该研究成功建立了一种生产高纯度149.9的方法.
- 放射性标记的DOTATATE与Tb-149显示为临床前向性阿尔法疗法的前景.
- 基于Tb-149的治疗方法的临床转化需要进一步开发.
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