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休息状态网络及其与PD患者MoCA表现的关系

Victor Galvez¹, César Romero-Rebollar^2,3, M Anayali Estudillo-Guerra⁴

¹Laboratorio de Neurociencias Cognitivas y Desarrollo, Escuela de Psicología, Universidad Panamericana, Ciudad de México, México. vgalvez@up.edu.mx.

Brain imaging and behavior

|February 9, 2024

概括

帕金森病 (PD) 中的轻度认知障碍显示出明显的脑网络变化. 休息状态网络连接在有或没有认知障碍的PD患者之间有所不同,这表明一种独特的神经退行性模式.

科学领域:

神经科学是一个神经科学.
神经学神经学
认知科学认知科学

背景情况:

轻度认知障碍 (MCI) 是帕金森病 (PD) 的一个常见的非运动症状.
与PD中MCI发作相关的静止状态网络 (RSN) 改变尚未得到充分理解.
了解这些变化对于诊断和管理PD认知衰退至关重要.

研究的目的:

为了研究患有PD的个体的RSN变化.
确定RSN变化与PD认知表现之间的关联.
在PD中区分认知障碍的神经生物学模式.

主要方法:

功能磁共振成像 (fMRI) 用于分析RSN.
研究了3组:PD患者的认知正常 (NC),PD患者的MCI,和健康的对照 (HC).
在默认模式网络 (DMN),突出网络 (SN) 和中央执行网络 (CEN) 中使用Z-score系数来评估连接性.

主要成果:

在PD患者中,无论认知状态如何,DMN和SN连接性都降低了.
在NC的PD中,DMN节点与全球认知负相关,而SN节点与全球认知正相关.
这种反向关系在PD与MCI中不存在. 执行功能与CEN连接相关,语言功能与MCI的PD中SN连接相关.

结论:

在PD的认知障碍与明显的RSN改变有关.
患有MCI的PD和NC的PD之间的RSN差异表明了差异化的神经退行模式.
这些发现突显了RSN作为帕金森病认知状态生物标志物的潜力.

关键词:

轻度认知障碍轻度认知障碍这就是MoCA MoCA.帕金森氏症帕金森氏症静止状态网络是静止状态网络.功能磁力共振成像 (fMRI) 是一种

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