格拉姆阴性细菌与慢性中耳炎中传感神经听力损失有关
Jintao Lou1,2, Wuhui He1,2, Bozhen Cui1,2
1Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
The Laryngoscope
|February 9, 2024
概括
慢性中耳炎中的グラム阴性细菌显著增加了严重神经感官听力损失 (SNHL) 的风险. 单细胞数量增加与格拉姆阴性感染和SNHL严重程度有关.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 听力学 听力学是指听力学.
背景情况:
- 慢性中耳炎 (COM) 是一种炎症性疾病,其特征是耳和听力损失.
- 在COM中的细菌感染可能导致内耳损伤和神经感应听力损失 (SNHL).
研究的目的:
- 为了比较SNHL患病率和严重程度的患者,与氏阴性与氏阳性细菌培养.
- 研究循环单细胞和中性粒细胞度,细菌物种和SNHL之间的关联.
主要方法:
- 胆固醇瘤或慢性支性中耳炎中耳病患者的回顾性研究.
- 分析中耳液培养物,纯音调听力测量和白细胞计数.
- 后勤回归用于识别SNHL风险因素.
主要成果:
- 细菌培养阳性感染是SNHL的一个独立风险因素 (OR=7.265,p=0.001).
- 格拉姆阴性细菌与格拉姆阳性细菌相比,与更高的SNHL风险 (p<0.0001) 和更大的严重程度 (p=0.005) 相关.
- 循环单细胞增加与グラム阴性感染和SNHL发生相关 (p=0.0343).
结论:
- 格拉姆阴性细菌与循环单细胞水平的增加有关.
- 在COM患者中,格兰阴性细菌感染具有较高的严重SNHL风险.
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