晚间血压下降,血压变化和早期和中年成年人的认知功能
Katerina Massengale1, Vernon A Barnes2, Celestin Williams2
1Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Journal of clinical hypertension (Greenwich, Conn.)
|February 9, 2024
概括
夜间血压 (BP) 和BP变化影响认知功能,即使在年轻和中年成年人. 这些BP模式也可能解释认知表现的种族差异.
科学领域:
- 心血管健康 心血管健康
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 夜间血压升高 (BP),血压下降降,血压变化增加与老年人的认知能力下降有关.
- 这些BP参数与年轻人和中年人的认知功能之间的关系仍然不太清楚.
- 非洲裔美国人和欧洲裔美国人之间存在血压和认知功能的种族差异.
研究的目的:
- 研究夜间血压,血压下降,血压变化和成年早期和中期认知功能之间的关联.
- 确定BP参数中的种族差异是否有助于认知功能中的种族差异.
主要方法:
- 在390名参与者 (25-50岁) 中利用了24小时的门诊血压监测和认知评估.
- 包括一个多元化的队列,54.9%的非洲裔美国人和63.6%的女性.
- 分析了血压参数 (夜间,白天,变化) 和认知测试成绩之间的关联.
主要成果:
- 较高的夜间血压,减少浸泡和增加的血压变化与图片序列记忆测试的分数较低有显著联系.
- 变性还显示了与整体认知复合分数的显著负面关联.
- 在24小时或白天平均血压和认知功能之间没有发现显著的联系.
- 夜间透析血压和浸泡的种族差异部分解释了图片序列记忆测试得分的种族差异 (6.81%10.8%).
结论:
- 夜间血压的有害影响,浸泡,以及对认知功能的变化在年轻和中年成年人中很明显.
- 夜间BP和浸泡模式有助于认知功能的种族差异.
- 门诊血压监测对于在年轻人群中识别异常血压模式至关重要,因为与白天或平均血压相比,它们与认知功能有更强的关联.
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