连续与单次肺炎球菌疫苗接种对老年人心血管疾病的影响:基于人口的队列研究
Xinning Tong1,2, Le Gao3, Ian C K Wong3,4,5
1Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
International journal of epidemiology
|February 9, 2024
概括
与单剂量疫苗相比,老年人用PCV13和PPSV23连续接种肺炎球菌疫苗显著降低了心血管疾病 (CVD) 风险. 这种双重方法除了预防肺炎之外,还提供了额外的CVD保护.
科学领域:
- 老年学是一门学科.
- 疫苗学 疫苗学 疫苗学
- 心血管医学 心血管医学
背景情况:
- 肺炎球菌疫苗接种指南很少提到并发症的好处.
- 研究序列性13肺炎球菌合疫苗 (PCV13) 和23肺炎球菌多糖体疫苗 (PPSV23) 对老年人心血管疾病 (CVD) 的影响.
研究的目的:
- 确定序列PCV13和PPSV23疫苗接种是否在老年人中提供比单个肺炎球菌疫苗更好的心血管保护.
主要方法:
- 在香港 (2012-2020年) 进行的回顾性队列研究,涉及65岁以上的成年人.
- 倾向性得分匹配用于比较单次与顺序双重疫苗接种组.
- 考克斯回归和结构方程建模以评估心血管疾病风险和通过减少肺炎的调解.
主要成果:
- 匹配的队列每组69390人,随访时间中位数为1.89年.
- 连续的双重疫苗接种与显著降低心血管疾病风险相关 (HR:0.75;95%CI:0.71,0.80;P<0.001).
- 肺炎发病率降低强烈影响了观察到的心血管疾病风险降低.
结论:
- 连续的双重肺炎球菌疫苗接种 (PCV13跟随PPSV23) 在老年人中显示出显著的心血管益处.
- 这一策略比单剂量疫苗提供更多的预防心血管疾病的保护.
- 考虑这些心血管益处对于优化肺炎球菌疫苗接种策略至关重要.
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