一项半自然主义的开放标签研究,检查处方医用大麻使用对模拟驾驶性能的影响
Brooke Manning1, Thomas R Arkell1, Amie C Hayley1,2
1Centre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia.
Journal of psychopharmacology (Oxford, England)
|February 9, 2024
概括
医用大麻的使用,特别是delta-9-tetrahydrocannabinol (THC) 产品,在模拟环境中对驾驶表现的影响微不足道. 患者表现出稳定的车辆控制和减少感知驾驶力度后,规定的使用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 交通安全 交通安全 交通安全
背景情况:
- 越来越多的医用大麻使用需要了解它对驾驶等关键功能的影响.
- 德尔塔-9-四大麻 (THC) 是大麻中主要的精神活性化合物,其对驾驶性能的影响仍在调查中.
- 医用大麻的稳定,处方剂量可能会改善认知和精神运动症状.
研究的目的:
- 评估含有THC的处方医用大麻对患者模拟驾驶表现的影响.
- 评估大麻消费后驾驶指标和感知驾驶力度的变化.
- 在消费后的生物样本中分析THC度.
主要方法:
- 一项半自然化的实验室研究,涉及40名成年患者使用他们处方的医用大麻.
- 驾驶模拟 (Forum8) 评估了横向位置的标准偏差 (SDLP),速度变化和平均速度在基线和剂量后 (2.5小时,5小时).
- 感知驾驶努力 (PDE) 是自我报告;THC水平在口服液和血液中被测量.
主要成果:
- 对于平均速度和PDE,注意到时间的显著影响,这表明车辆控制稳定和PDE后剂量减少的适度.
- 与花制品相比,使用油基产品的患者显示SDLP和PDE的升高.
- 在服用后6小时内,THC在口服液中可检测到.
结论:
- 含有THC的处方医用大麻 (1.13-39.18毫克/剂量) 似乎对驾驶性能影响微不足道.
- 这项研究表明,当按照规定使用时,医用大麻不会显著损害驾驶能力.
- 产品形式的差异 (油与花) 可能会影响驾驶性能指标.
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