孕产妇COVID-19疫苗接种和预防婴儿症状感染
Cristina V Cardemil1, Yi Cao2, Christine M Posavad2
1National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
母亲COVID-19疫苗接种可以提高婴儿抗体水平,在前六个月显著降低感染风险. 增强剂进一步增强了这种对SARS-CoV-2的被动保护.
科学领域:
- 免疫学 免疫学 免疫学
- 孕产妇和儿童的健康
- 传染性疾病 传染性疾病
背景情况:
- 在怀孕期间对母亲进行疫苗接种是一种保护婴儿免受传染病的策略.
- 在生命早期,保护婴儿免受严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 的影响至关重要.
研究的目的:
- 量化母性衍生疫苗诱导抗体对婴儿冠状病毒病2019 (COVID-19) 感染的保护作用.
- 为了评估生命前六个月的保护.
主要方法:
- 接种mRNACOVID-19疫苗 (2或3剂量) 的母亲产生的婴儿在分娩时测量了抗体标位.
- 婴儿SARS-CoV-2感染被追踪到6个月的潜在随访.
- 风险降低的估计是基于母亲的疫苗接种剂量和婴儿抗体标位水平.
主要成果:
- 孕育后母亲的婴儿的抗体标位较高,感染的可能性降低了56%.
- 在分娩时,抗体标位 (Spike IgG,伪病毒,活病毒) 每增加10倍都与婴儿感染风险显著降低 (30%-60%) 相关联.
- 观察到对各种SARS-CoV-2菌株的保护,包括Omicron变种.
结论:
- 更高的胎盘抗体标位大大降低了婴儿SARS-CoV-2感染风险.
- 孕产妇接种疫苗,特别是用辅助剂量,在病毒占主导地位的时期加强了保护.
- 在婴儿有资格接种疫苗之前,母婴接种疫苗为婴儿提供了至关重要的被动免疫力.
更多相关视频
13:00Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
Published on: July 31, 2021
05:51Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
相关概念视频
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Vaccinations
Active versus Passive Immunity
Active Immunity
Active immunity refers to the resistance one develops...
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Transmission-based Precautions I: Contact, Enteric, and Droplets
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
