相关实验视频
Updated: May 10, 2026
06:35
Basics of Multivariate Analysis in Neuroimaging Data
Published on: July 24, 2010
16.9K
在2型糖尿病中基于皮层厚度的结构共变性网络的变化
Yang Huang1, Xin Zhang1, Miao Cheng1
1Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
Frontiers in neuroscience
|February 9, 2024
概括
没有认知障碍的2型糖尿病 (T2DM) 患者表现出局部大脑网络组织障碍. 这些皮质厚度和网络效率的变化可能是T2DM早期认知功能障碍的基础.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 内分泌学 在内分泌学.
背景情况:
- 认知障碍是2型糖尿病 (T2DM) 的常见并发症.
- 在T2DM中早期的认知功能障碍可能源于大脑皮层结构的微妙变化.
- 在没有轻度认知障碍 (MCI) 的T2DM患者中研究这些变化对于了解疾病进展至关重要.
研究的目的:
- 在没有MCI的T2DM患者中调查基于皮层厚度的结构拓网络变化.
- 确定受T2DM影响的特定大脑区域和网络属性.
- 探索改变的网络参数与认知/临床变量之间的关系.
主要方法:
- 追溯研究涉及56名T2DM患者和59名健康对照.
- 神经心理评估和3D T1加权结构MRI.
- 基于皮层厚度的结构共变性网络的图形理论分析.
主要成果:
- T2DM患者表现出较低的聚类系数 (C) 和局部效率 (Elocal).
- 节点性质的破坏观察到在头部,部,前部区域,前部,前中心部和岛屿部.
- 改变的网络参数与神经心理测试结果相关,这表明局部网络组织受损,尽管全球网络相对正常.
结论:
- 没有MCI的T2DM患者在结构性大脑网络中表现出局部干扰,特别影响当地组织和效率.
- 腹部视觉通路的损伤可能导致T2DM的视觉认知缺陷.
- 这些发现描述了与T2DM早期认知功能障碍相关的灰质结构变化.
相关概念视频
01:22Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
01:26Type I Diabetes II: Pathophysiology
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
01:19Type I Diabetes III: Clinical Manifestations
Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
01:26Type II Diabetes I: Introduction
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
01:24Type II Diabetes II: Pathophysiology
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
01:25Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...