在新生儿和儿科患者中药理性治疗Sialorrhea
Caitlyn V Bradford1, Avery M Parman2, Peter N Johnson2
1Department of Pharmacy Practice (CVB), Philadelphia College of Pharmacy at Saint Joseph's University, Philadelphia, PA.
概括
非注射药物可以在患有神经系统疾病的儿童中治疗 (过多的唾液). 甘酸是一种经过充分研究,有效的第一线选择,具有良好的耐受性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 儿科神经学 儿科神经学
- 胃肠病学 胃肠病学
背景情况:
- 脑或过多的唾液在患有脑和其他神经疾病的儿科患者中很常见.
- 它会导致诸如皮肤问题,感染,吸血,肺炎和脱水等并发症.
- 非药物治疗往往是不够的,需要医疗干预.
研究的目的:
- 审查用于治疗儿科小腹的非注射药理学药剂.
- 详细介绍药物的有效性,安全性和实际使用方面的考虑.
- 根据当前的文献,确定最佳的治疗策略.
主要方法:
- 对已发表的英语人体研究进行系统的文献综述.
- 搜索的数据库是:PubMed和谷歌学者 (1997-2022年).
- 包括15项涉及719名儿科患者的研究.
主要成果:
- 葡萄糖酸盐,氨酸,斯科波胺和三基是潜在的治疗方法.
- 葡萄糖酸盐是研究最多的药物,在52%的患者中使用.
- 甘酸的疗效与其他药物相当,但耐受性更好.
结论:
- 葡萄糖酸盐通常被认为是儿科病的第一线药理疗法.
- 选择治疗需要仔细考虑患者的年龄,途径和药物特点.
- 由于潜在的不良事件和剂量依赖的影响,建议以较低剂量开始治疗.
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