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当前的做法和药物使用的安全性在儿科快速序列输管过程中
Sarah A Bisesi1, Sierra D Stauber2, David J Hutchinson3
1Department of Pharmacy (SAB), University of Rochester Medical Center, Rochester, NY.
概括
儿科快速序列输管 (RSI) 药物治疗实践在全国范围内有所不同. 诱导剂和神经肌肉阻断剂的使用在新生儿重症监护病房和其他儿科病房之间存在显著差异,影响了患者的护理.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 药理学 药理学是指药理学的学科.
- 重症监护室的重症监护室的重症监护室.
背景情况:
- 快速序列输管 (RSI) 是儿科护理中的一个关键程序.
- 了解RSI期间的药物治疗实践对于优化患者的治疗结果至关重要.
- 药物使用的变化可能导致不理想的护理和不良事件.
研究的目的:
- 描述儿科RSI期间和之后的药物治疗实践.
- 评估与RSI药物相关的不良药物事件的发生率.
- 确定影响儿科RSI药物选择的因素.
主要方法:
- 美国儿科和新生儿重症监护室 (NICU) 和急诊室的多中心观察性研究.
- 包括172名接受RSI的患者.
- 收集有关预诱导,诱导和神经肌肉阻断剂 (NMBA) 管理以及不良事件的数据.
主要成果:
- 在NICU (52%,23%) 和非NICU (98%,95%) 设置之间,诱导和NMBA使用的显著差异.
- 芬太尼和米达佐拉姆是最常见的诱导剂;罗库是最常用的NMBA.
- 尽管使用了低水平的热素,但不良事件如心肌梗塞很少发生;低血压/高血压发生在23-24%的人中.
结论:
- 儿科RSI药物治疗实践在美国表现出显著的差异.
- 患者的位置 (NICU与非NICU),年龄和体重似乎会影响药物选择.
- 需要进一步的研究来规范实践,并提高儿科RSI期间的患者安全.
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