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预测 COVID-19 后疲劳和认知缺陷无法恢复的预测因素:一个前性,纵向性,基于人口的研究

Tim J Hartung¹, Thomas Bahmer^2,3, Irina Chaplinskaya-Sobol⁴

¹Charité - Universitätsmedizin Berlin, Department of Neurology and Experimental Neurology, Berlin, Germany.

EClinicalMedicine

|February 9, 2024

概括

长期COVID疲劳和认知缺陷随着时间的推移而改善,大约一半的人在两年内恢复. 确定了无法恢复的风险因素,以帮助制定有针对性的治疗策略.

科学领域:

神经学神经学
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

长期COVID疲劳和认知缺陷是SARS-CoV-2感染的普遍和致残的后果.
对于这些感染后疾病的长期恢复轨迹的了解有限.

研究的目的:

评估SARS-CoV-2感染后疲劳和认知缺陷的长期恢复模式.
确定与这些持续症状无法恢复相关的风险因素.

主要方法:

德国基于人口的COVIDOM/NAPKON-POP队列的纵向分析.
使用慢性疾病治疗-疲劳 (FACIT-Fatigue) 尺度的功能性评估评估疲劳的评估,以及在基线 (≥6个月) 和感染后的随访 (≥18个月) 蒙特利尔认知评估 (MoCA) 的认知功能.
使用后勤回归模型来确定恢复的预测因素.

主要成果:

在基线时,21%的人经历过疲劳,23%的人有认知缺陷. 随访后观察到显著改善,46%的人从疲劳中恢复,57%的人从认知缺陷中恢复.
不恢复的风险因素包括抑郁症状和疲劳的头痛,以及男性性别,年龄较大和认知缺陷的教育程度较低.
重新感染SARS-CoV-2并没有显著影响康复率.

结论:

在SARS-CoV-2感染后,疲劳和认知缺陷在大约两年内有所改善,恢复率很高.
确定特定的风险因素对于开发针对性干预和长期COVID患者的预防策略至关重要.
这项研究为这些常见的长期COVID症状的自然历史和恢复预测因素提供了宝贵的见解.

关键词:

在 COVID-19 疫情中,认知功能障碍认知功能障碍疲劳疲劳疲劳疲劳疲劳纵向研究是指长度研究.后急性COVID-19综合征是什么

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