患有COVID-19住院的系统性硬化症患者的结果:来自国家住院患者样本的洞察
Huzaifa Ahmad Cheema1, Anum Akhlaq2, Biah Mustafa1
1Department of Medicine, King Edward Medical University, Lahore, Pakistan.
与没有自身免疫性疾病的患者相比,因COVID-19而住院的系统性硬化症患者经历了更糟糕的结果,包括较高的重大不良事件发生率.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 类风湿病学 类风湿病学
背景情况:
- COVID-19 (冠状病毒疾病2019) 呈现了一系列疾病,从轻度到严重的呼吸衰竭.
- 系统性硬化症是一种慢性自身免疫性疾病,与感染风险增加有关.
- 了解免疫受损人群中COVID-19的结果至关重要.
研究的目的:
- 为了比较COVID-19住院治疗的临床结果和资源利用情况.
- 为了研究患有系统性硬化症和没有系统性硬化症的患者之间的差异.
主要方法:
- 利用了2020年国家住院样本数据库.
- 分析的特征,发病率,死亡率,成本和资源利用.
- 与系统性硬化症和没有系统性硬化症的COVID-19住院情况进行比较.
主要成果:
- 分析了1,050,040名COVID-19患者,775名 (0.07%) 患有全身性硬化症.
- 在系统性硬化症队列中,住院死亡率,血管压缩剂使用,心脏骤停和急性损伤率数量较高.
- 主要不良事件的综合终点在全身性硬化症患者中显著更高 (aOR 1.52,p=0.022).
结论:
- 患有系统性硬化症的COVID-19患者表现出更糟糕的临床结果.
- 在全身性硬化症组中观察到较高的主要不良事件的复合终点.
- 需要进一步的研究来阐明COVID-19和全身性硬化症之间的关系.
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