系统性硬化症的探索性临床亚组聚类:来自印度进步性系统性硬化症注册表的结果
Shery Susan Philip1, Ramya Janardana1, Padmanabha Shenoy2
1Department of Clinical Immunology and Rheumatology, St. John's Medical College Hospital, Bengaluru, India.
Journal of scleroderma and related disorders
|February 9, 2024
概括
这项研究根据临床和免疫学标志物确定了四个不同的系统性硬化症 (SSc) 患者群. 这些发现支持SSc分类,并突出显示了抗毒素酶I,有限的皮肤SSc和间歇性肺病之间的关联.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 系统性硬化症研究研究
背景情况:
- 系统性硬化症 (SSc) 是一种复杂的自身免疫性疾病,具有显著的异质性.
- 精确分类SSc患者对于了解疾病进展和治疗策略至关重要.
研究的目的:
- 进行系统性硬化症患者的探索性集群分析,使用来自印度SSc注册的基线数据.
- 根据临床和免疫学参数识别出不同的患者亚组.
主要方法:
- 利用来自印度SSc注册的基线数据,包括404名符合美国风湿病学学院-欧洲反风湿联盟分类标准的患者.
- 采用探索性集群分析,根据临床和免疫学特征对患者进行分组.
主要成果:
- 确定了四个不同的群体:三种主要是抗毒素酶I (抗T) 阳性和一种抗中位素抗体 (ACA) 2 主导.
- 集群1 (扩散皮肤SSc,抗T) 显示严重的皮肤疾病和肌肉骨,血管病和胃肠道特征的高患病率.
- 集群4 (有限的皮肤SSc,ACA占主导地位) 代表了最不严重的群体,发病年龄较高,上部胃肠道特征较高.
结论:
- 探索性集群分析证实了系统性硬化症在频谱上的分类潜力.
- 这项研究证实了在有限的皮肤SSc中存在抗毒素酶I的存在,以及其与间歇性肺部疾病的关联.
相关概念视频
Classification of Illness
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...
Documentation of Nursing Diagnosis
The nurse documents nursing diagnoses and enters them into the patient record. The identified patient's nursing diagnosis is either written out with a plan of care or entered into the electronic health record.
In some settings, data-driven computerized decision support systems are in place, allowing for more accurate nursing diagnoses. The database within one of these systems includes diagnostic labels defining characteristics, activities, and indicators for nursing. A nurse enters assessment...
In some settings, data-driven computerized decision support systems are in place, allowing for more accurate nursing diagnoses. The database within one of these systems includes diagnostic labels defining characteristics, activities, and indicators for nursing. A nurse enters assessment...
Nursing Clinical Information System
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
Classification of Systems-I
Linearity is a system property characterized by a direct input-output relationship, combining homogeneity and additivity.
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
Classification of Systems-II
Continuous-time systems have continuous input and output signals, with time measured continuously. These systems are generally defined by differential or algebraic equations. For instance, in an RC circuit, the relationship between input and output voltage is expressed through a differential equation derived from Ohm's law and the capacitor relation,
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:


