在一般人群中,慢性咳与COPD恶化,肺炎和死亡有关
Eskild M Landt1, Yunus Çolak2,3, Børge G Nordestgaard3,4,5
1Department of Clinical Biochemistry, Zealand University Hospital, Køge, Denmark.
ERJ open research
|February 9, 2024
概括
慢性咳,定义为持续超过8周,在一般人群中显著增加了COPD恶化,肺炎和全因死亡的风险. 这些发现凸显了慢性咳是需要医疗照顾的严重健康问题.
科学领域:
- 肺部病理学 肺部病理学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 慢性咳,影响高达10%的人口,现在被认为是一种独特的疾病实体.
- 它可能会增加严重健康结果的风险,包括发病率和死亡率.
- 以前的看法认为慢性咳主要是其他疾病的症状.
研究的目的:
- 调查慢性咳与患慢性阻塞性肺病 (COPD) 恶化的风险之间的关联.
- 为了确定慢性咳是否与肺炎发病率增加有关.
- 评估慢性咳与一般人群全因死亡率之间的关系.
主要方法:
- 在哥本哈根一般人口研究的44,756名参与者中,确定了一组2801名患有慢性咳 (>8周) 的个人.
- 在随访期间收集了COPD恶化,肺炎诊断和全因死亡率的数据.
- 进行了统计分析,包括调整的危险比率,以评估与慢性咳相关的风险.
主要成果:
- 在平均3.4年的随访期间,患有慢性咳的个体在80岁时显示出COPD恶化,肺炎和全因死亡率的累积发病率明显较高.
- 调整后的危险比率表明,慢性咳患者患COPD恶化的风险增加了4.6倍,肺炎的风险增加了2.2倍,所有死因的风险增加了1.7倍.
- 即使在目前有空气流量限制的吸烟者中,慢性咳也与这些不良结果的绝对5年风险相对较高.
结论:
- 慢性咳独立地与COPD恶化,肺炎和死亡的风险增加有关.
- 这些关联无论空气流量限制和吸烟状况等因素如何,都会持续存在.
- 这些发现强调了认识到慢性咳作为严重健康后果的重大风险因素的重要性.
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