肺功能轨迹集群在中年和老年人中的临床相关性
Xander Bertels1,2, James C Ross3, Rosa Faner4,5,6
1Department of Bioanalysis, Ghent University, Ghent, Belgium.
ERJ open research
|February 9, 2024
概括
这项研究在45岁以上的成年人中确定了八种肺功能轨迹. 一些轨迹,如持续低或快速下降的1秒内强制呼气量 (FEV1),与较高的死亡风险有关.
科学领域:
- 肺病学和呼吸系统医学
- 流行病学和公共卫生.
- 老年学是一门学科.
背景情况:
- 在一般成年人群中,了解肺功能轨迹及其健康结果仍然有限.
- 这项研究侧重于45岁及以上的成年人,以识别随着时间的推移,肺功能变化的独特模式.
研究的目的:
- 在45岁及以上的成年人中识别和描述肺功能轨迹的不同集群.
- 研究这些肺功能轨迹与各种健康结果 (包括死亡率和呼吸道疾病) 之间的关联.
主要方法:
- 采用了从前性,基于人群的鹿特丹研究 (n=3884) 中的螺旋计数据 (FEV1,FVC,FEV1/FVC比率) 的高斯有限混合物建模.
- 分析的长度结局包括全因死亡率,呼吸系统症状,慢性肺炎,保留比率受损螺旋计 (PRISm),戒烟和体重变化.
- 独立的风险因素,包括遗传倾向 (多基因分数),人口统计,生活方式和心血管因素,使用多重后勤回归进行了评估.
主要成果:
- 确定了八个肺功能轨迹集群,其中42.8%显示持续正常的螺旋计.
- 三个群体显示死亡风险增加:持续低FEV1 (HR 1.71),快速下降FEV1 (HR 1.48) 和FVC下降 (HR 1.49) .
- 持续高的FEV1和FVC改善剂显示出对死亡率的保护作用 (HR分别为0.82和0.61). 轨迹与遗传,人口,生活方式和临床因素有关.
结论:
- 这项研究成功地在老年成人群体中确定了临床相关的肺功能轨迹集群.
- 这些不同的轨迹与不同的死亡风险有关,并受到遗传,生活方式和临床因素的组合的影响.
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