胃腺癌与肠芽细胞分化通过内镜下粘膜切割切除:一个案例报告
Akira Ishikawa1, Koki Nakamura2
1Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Case reports in gastroenterology
|February 9, 2024
概括
胃腺癌与肠芽细胞分化 (GAED) 是一种罕见的,激进的胃癌. 通过免疫染进行早期检测对于有可疑发现的患者至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 胃腺癌与肠芽细胞分化 (GAED) 是一种罕见且具有攻击性的胃癌亚型.
- 诊断通常是基因病理学,通常处于先进阶段.
研究的目的:
- 报告一个被诊断并通过内镜下粘膜剖析治疗的GAED病例.
- 突出免疫组织化学在诊断GAED中的重要性.
主要方法:
- 肠道病理学检查一个内镜下膜剖析样本.
- 用于Glypican-3和α-fetoprotein的免疫组织化学染色.
主要成果:
- 一名70岁的男性出现了表面压缩的胃病变.
- 组织学揭示了扩张的管道和清晰的细胞质,与GAED一致,对Glypican-3和α-fetoprotein呈阳性.
- 瘤显示有淋巴侵袭,但患者在治疗后1年内仍然没有复发.
结论:
- 根据形态学,建议在疑似GAED病例时进行积极的免疫染.
- 内镜下粘膜切割可以成为可切割的GAED的可行的治疗选择.
- 由于其具有侵略性的潜力,GAED需要谨慎的跟进.
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