概括
这篇文章已被撤回. 它不再被认为是一个有效的科学出版物.
科学领域:
- 在科学出版物中的撤回通知.
背景情况:
- 标识DOI: 10.2147/DDDT.S156123的原始产品已经不再可用了.
研究的目的:
- 本公告的目的是正式撤销上述条款.
主要方法:
- 没有方法适用,因为该物品是收缩的.
主要成果:
- 没有结果适用,因为文章是收回的.
结论:
- 文章已被撤回,不应该引用.
相关概念视频
Factors Affecting Dissolution: Particle Size and Effective Surface Area
846
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
846
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
208
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
208


