相关实验视频

Updated: Jul 4, 2025

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

在注意力缺陷多动性障碍中,皮层梯度扰乱与神经递质,细胞类型和染色体转录特征相关

Zhiyi Chen^1,2, Ting Xu^3,4, Xuerong Liu¹

¹Experimental Research Center of Medical and Psychological Science, School of Psychology, Third Military Medical University, Chongqing, China.

Psychiatry and clinical neurosciences

|February 9, 2024

概括

儿童的注意力缺陷多动性障碍 (ADHD) 显示出与遗传和分子因素相关的大脑连接模式的改变. 这些变化影响认知和情绪,揭示了ADHD复杂的神经生物学基础.

科学领域:

神经成像是一种神经成像.
神经生物学神经生物学神经生物学
遗传学遗传学是一个

背景情况:

注意缺陷多动症 (ADHD) 是一种复杂的神经发育障碍.
了解ADHD的神经病理基础对于开发有效的干预措施至关重要.

研究的目的:

使用多尺度方法研究ADHD的神经病理景观.
将宏观大脑连接模式与ADHD的微观和分子特征联系起来.

主要方法:

利用了来自ADHD-200倡议的休息状态功能连接 (rs-fc) 神经成像数据.
采用扩散映射嵌入模型来导出功能连接体梯度.
应用多变量部分最小平方分析来识别神经递质,细胞和染色体特征.

主要成果:

与典型的发育个体相比,ADHD儿童在涉及认知的网络中表现出显著的皮质梯度扰乱.
这些梯度变化在GABAergic和 serotonergic受体分布中得到丰富,并与基因表达模式共同变化.
研究结果表明,存在细胞特异性 (寡类细胞前体,内皮细胞) 和染色体 (18,19,X) 功能障碍的风险.

结论:

这项研究将宏观神经病理学与ADHD中的微观/细胞生物学联系起来.
确定了涉及GABA和5-HT系统中的遗传和分子变异的神经生物学机制.
突出了特定细胞和染色体表达在ADHD病变发生过程中的作用.

关键词:

艾伦人类大脑图书馆人类大脑图书馆注意力缺陷/多动症障碍.皮层功能梯度的皮层功能梯度.图像衍生的表型图像衍生的表型神经连接体的神经连接体

更多相关视频

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol

Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol

Published on: April 1, 2018

相关概念视频

Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....

Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

Neurotransmitters

Neurotransmitters

Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.