陶积累和缩预测粉样蛋白独立的认知衰退在衰老
Corrina S Fonseca1, Suzanne L Baker2, Lindsey Dobyns1
1Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|February 9, 2024
概括
叶的纵向病理与老年人的记忆力下降有关,不论粉样β (Aβ) 水平如何. 然而,只有当Aβ升高时,粉样β (Aβ) 才会影响认知衰退.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 放射学 放射学是一门学科.
背景情况:
- 粉样β (Aβ) 和tau病理是衰老和阿尔茨海默病 (AD) 的标志,与认知能力下降有关.
- 了解这些病理和认知变化之间的纵向关系对于早期检测和干预至关重要.
研究的目的:
- 为了研究粉样β (Aβ) 和蛋白PET成像,大脑缩和认知衰退在认知健康的老年人之间的并发纵向关系.
- 确定Aβ状态是否会改变tau病理与认知衰退之间的关联.
主要方法:
- 利用匹兹堡化合物B (PiB) PET用于Aβ,flortaucipir (FTP) PET用于tau,以及78名认知健康的老年人缩的结构MRI.
- 评估了情节性记忆 (EM) 和非记忆 (NM) 认知功能的纵向变化.
主要成果:
- 肠道变化与EM下降相关,无论Aβ状态如何.
- 超时和全球Aβ (PiB) 变化只与高Aβ (Aβ+) 个体的EM和NM下降有关.
- 在所有参与者中,无论Aβ状态如何,Voxel-wise时间变化与EM下降相关. 在Aβ/tau积累和大脑结构变化之间没有发现任何关联.
结论:
- 在叶中长度积是老年人记忆力衰退的重要预测因素,独立于Aβ负担.
- 纵向Aβ积累对认知衰退 (记忆和非记忆) 的影响只有在Aβ水平升高时才明显.
- 这些发现表明,和Aβ病理影响认知的独特和潜在的相互作用机制,强调在记忆衰退中的作用,即使没有显著的Aβ.
相关概念视频
01:26Alzheimer's Disease: Overview
484
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
484
01:22Alzheimer's Disease: Treatment
189
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
189
01:30Cognitive Development During Adulthood
111
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
111
03:03Amyloid Fibrils
9.5K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.5K
01:30Dementia
113
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
113