乳腺癌检测使用低剂量正子辐射数字乳房扫描系统
Vivianne Freitas1, Xuan Li1, Anabel Scaranelo1
1From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada (X.L.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (S.T., O.B., A.R.); Lakehead University, Thunder Bay, Canada (O.B., B.B., A.R.); Radialis Inc, Thunder Bay, Canada (O.B., B.B., B.K., S.P., C.A.M., M.W., K.O.O.); Institute of Biomedical Engineering, University of Toronto, Toronto, Canada (C.A.M.); and Posluns Centre for Image-Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Canada (C.A.M.).
低剂量正子发射乳房扫描 (PEM) 显示了与MRI同时检测侵入性乳腺癌的可行性. 这种成像工具对乳腺癌诊断有前途,尽管需要进行更大规模的试验.
科学领域:
- 在瘤学瘤学.
- 医疗成像医学成像
- 放射学 放射学是一门学科.
背景情况:
- 乳腺癌的诊断依赖于精确的成像技术.
- 磁共振成像 (MRI) 是一种标准工具,但正在探索补充方法.
- pozitron发射乳房学 (PEM) 提供功能性成像洞察力.
研究的目的:
- 评估低剂量正子发射乳房造影 (PEM) 与MRI一起用于乳腺癌检测的可行性.
- 确定低剂量PEM在识别乳腺癌局部扩散的能力.
- 为了评估PEM与MRI结合的诊断性能.
主要方法:
- 一项前性研究,涉及25名新诊断乳腺癌的女性参与者.
- 低剂量F-FDG PEM与乳房MRI同时进行.
- 两位放射科医生在注射后1小时和4小时审查PEM图像,与他的病理学相关联.
- 检测准确度和病变检测效率与PEM和MRI之间的比较.
主要成果:
- 低剂量PEM发现了96%的癌症 (25中的24种),包括19种侵袭性疾病和5种现场疾病.
- 即使在辐射追踪器吸收3小时后,也观察到可比的检测性能.
- 与MRI相比,PEM检测到的假阳性额外病变较少 (16%与62%相比,P = .14).
- 此外,PEM还忽略了另外三种现场2级病变.
结论:
- 低剂量PEM证明了作为检测侵入性乳腺癌的辅助工具的可行性.
- 这种成像模式显示出作为乳腺癌诊断中的有希望的工具的潜力.
- 进一步的大规模临床试验是必要的,以验证这些初步发现.
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