来自大豆的抗高血压解剂通过调节MAPK和NF-κB信号通路来减轻Ang II诱导的损伤
Tianyuan Song1,2, Yin-Yi Ding1,2, Tiantian Zhang1
1School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, People's Republic of China. guzy84@163.com.
Food & function
|February 9, 2024
概括
大豆蛋白水解剂 (SPH) 有效降低血压,并保护高血压大鼠的损伤. 此外,SPH还可以降低细胞中的炎症和氧化应激,为高血压引起的损伤提供一种潜在的治疗方法.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管研究研究心血管研究
- 营养科学 营养科学
背景情况:
- 高血压诱导的损伤是无法控制的高血压的严重并发症,通常与氨酸 - 血管新生素系统 (RAS) 相关.
- 虽然已知抗高血压,但它们对损伤的特殊保护作用需要进一步研究.
研究的目的:
- 研究大豆蛋白衍生水解盐 (SPH) 对高血压引起的损伤的保护作用.
- 在动物模型和细胞培养中探索SPH作用的潜在机制.
主要方法:
- 口服SPH给自发高血压大鼠 (SHRs).
- 在体外研究使用安二酶 (Ang II) 诱导的HK-2细胞.
- 病理检查,免疫组织化学和炎症标志物和信号通路 (MAPK/JNK,NF-κB) 的分析.
主要成果:
- 在SHRs中,SPH显著降低了血压,并减轻了病理损伤.
- SPH减弱了炎症细胞透,抑制了MCP-1,并在SHR脏中增加了Nrf2表达.
- 在体外,SPH降低了Ang II诱导的炎症性细胞因子和活性氧物种 (ROS) 生产,调节了MAPK/JNK和NF-κB通路.
结论:
- 豆蛋白衍生水解剂 (SPH) 显示出显著的抗高血压特性,并改善损伤.
- SPH通过减少炎症,氧化应激和调节关键信号通路来发挥保护作用,这些通路涉及高血压引起的损伤.
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