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在马尔默饮食癌症研究中,可以从不同的eGFR公式中预测大动脉硬性,随着长时间的随访

Anders Christensson^1,2, Simon Lundgren^1,2, Madeleine Johansson^1,3

¹Department of Clinical Sciences, Lund University, Malmö, Sweden.

|February 9, 2024

概括

根据肌素,但不是囊素C,较低的估计膜过率 (eGFR) 预测大动脉硬度增加. 这一发现凸显了基于肌素的eGFR对评估血管衰老和心血管风险的重要性.

科学领域:

心血管健康心血管健康
腎臟病學 (nephrology) 是一種醫學.
衰老研究研究衰老研究

背景情况:

血管衰老,以大动脉硬表示,是心血管事件的重要预测因素.
估计的膜过率 (eGFR) 是功能的一个关键标志物.
不同的eGFR方程对血管衰老的预测值需要进一步研究.

研究的目的:

调查使用肌素 (eGFRCR) 和囊素C (eGFRCYS) 计算的eGFRFR对血管衰老 (大动脉硬) 和中央血液动力学的影响.
评估各种eGFR方程,包括CAPA,LMrev和EKFC,用于预测大动脉硬度.

主要方法:

分析了马尔默饮食和癌症研究的2064名参与者的数据,测量了带-大腿脉冲波速度 (cfPWV) 和中心血压.
使用多个已确定的方程的肌素和囊素C计算eGFR.
统计分析以确定eGFR和cfPWV之间的关联,并根据相关的共变量进行调整.

主要成果:

低调整的eGFRCR独立地与更高的cfPWV相关 (P < .001).
eGFR <60 mL/min/1.73 m2预测较高的cfPWV,除非使用EKFC方程.
关于eGFRCYS与eGFRCR方程的比率并不能预测大动脉硬度.

结论:

基于肌的eGFR是未来大动脉硬性的重要独立预测因子.
基于cystatin C的eGFR和不同eGFR方程的比率在这个队列中与大动脉硬性没有关联.
这些发现强调了基于肌素的eGFR在评估血管衰老和心血管风险方面的临床相关性.

关键词:

大动脉硬性大动脉硬氨酸C 氨酸C 氨酸流行病学流行病学估计的淋巴膜过率.功能功能功能

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