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相关概念视频

Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

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Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Antihypertensive Drugs: Action of Calcium Channel Blockers01:18

Antihypertensive Drugs: Action of Calcium Channel Blockers

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Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
518
Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

5.1K
Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
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Smooth Muscle Contraction01:25

Smooth Muscle Contraction

3.0K
Smooth muscle contraction is a complex process vital for various bodily functions, from maintaining blood vessel tension to facilitating the movement of food through the digestive tract. Unlike striated muscles, smooth muscle contraction begins more slowly and lasts longer.
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
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Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

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Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
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相关实验视频

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Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry
10:24

Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry

Published on: October 28, 2014

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让流动,让流动.

Régis Nouvian1

  • 1Institute for Neurosciences of Montpellier, Univ Montpellier, Inserm, CNRS, Montpellier, France.

eLife
|February 9, 2024
PubMed
概括

两个结合蛋白,calbindin家族蛋白1和2 (CaBP1和CaBP2),共同工作,保持内耳毛细胞中的通道的开放状态,这对听力至关重要.

科学领域:

  • 神经科学是一个神经科学.
  • 细胞生物学 细胞生物学
  • 审计科学 审计科学

背景情况:

  • 内耳毛细胞对于听力至关重要.
  • 通道在毛细胞功能中起着至关重要的作用.
  • 结合蛋白参与细胞信号传递.

研究的目的:

  • 研究CaBP1和CaBP2在调节毛发细胞中的通道中的作用.
  • 了解CaBP1和CaBP2在听觉功能中的合作机制.

主要方法:

  • 头发细胞中的电生理记录.
  • 免疫组织化学定位CaBP1和CaBP2.
  • 基因操纵用于研究蛋白质功能.

主要成果:

  • 发现CaBP1和CaBP2在内耳毛细胞中同定位.
  • 这两种蛋白质都是保持特定通道在开放状态所必需的.
  • 干扰CaBP1/CaBP2功能会影响通道活动.

结论:

  • CaBP1和CaBP2形成了一个功能复合体,以调节毛细胞通道.
关键词:
结合蛋白质是一种结合的蛋白质.通道中的.谷氨酸酸盐的使用方法头发细胞 头发细胞 头发细胞听到 听到 听到 听到 听到 听到 听到这里是鼠标鼠标鼠标鼠标鼠标鼠标.神经科学 神经科学

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  • 这种合作行动对于维持正常的审计功能至关重要.