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使用可变形与刚性图像登记在结直肠肝转移热除中的消耗边缘量化:一个回顾性单中心研究
Yuan-Mao Lin1, Iwan Paolucci1, Jessica Albuquerque Marques Silva1
1Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
生物机械可变形图像注册 (DIR) 优于刚性图像注册 (RIR) 在结直肠肝转移热移中量化最小的废除边缘,改善了局部瘤结果的预测.
科学领域:
- 医学成像医学成像
- 干预性瘤学 干预性瘤学
- 肝胆道手术是肝胆道的手术.
背景情况:
- 热性切除是结直肠肝转移 (CLM) 的关键治疗方法.
- 精确评估除边缘对于预测治疗成功和预防局部瘤进展至关重要.
- 图像注册技术对于量化在手术内CT扫描中的最小除边缘 (MAM) 非常重要.
研究的目的:
- 为了比较生物力学可变形图像注册 (DIR) 与基于强度的刚性图像注册 (RIR) 在量化MAM的有效性.
- 评估通过DIR和RIR对MAM量化的相关性,以及CLM热性废除后的局部瘤结局.
主要方法:
- 追溯分析了72名患有139名CLM的患者,这些患者接受了热消融治疗.
- 使用DIR和RIR对手术内对比度增强CT图像进行MAM的量化.
- 使用子相似系数 (DSC) 的注册准确性和使用曲线下的面积 (AUC) 预测局部瘤结果的比较.
主要成果:
- 与RIR (DSC 0.67-0.98) 相比,DIR显示出更高的注册准确性 (DSC 0.96-0.98),而RIR则显示出更高的注册准确性.
- 与RIR (0.72) 相比,DIR显示了预测残留瘤和1年局部瘤进展 (LTP) 的更高AUC (0.89).
- 通过DIR (19%) 与RIR (33%) 记录的肝脏外瘤较少.
结论:
- 生物机械可变形图像注册 (DIR) 比刚性图像注册 (RIR) 更准确和可靠,用于量化CLM热除中的最小除边缘.
- 在预测局部瘤结果方面,DIR显著优于RIR,包括残留瘤和LTP.
- 在CLM治疗中,DIR应被认为是用于基于CT的手术内切除确认的首选图像记录方法.
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