与慢性胰腺炎中不良妊娠结果相关的遗传因素
Di Wu1,2, Nan Ru3,4, Yuan-Chen Wang1,2
1Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.
Clinical and translational gastroenterology
|February 9, 2024
概括
慢性胰腺炎 (CP) 患者的遗传突变显著增加了不良妊娠结果的风险,特别是早产和堕胎. SPINK1突变与这些负面结果有很强的关联.
科学领域:
- 遗传学 是一个遗传学.
- 产科 产科 产科 产科 产科
- 胃肠病学 胃肠病学
背景情况:
- 影响慢性胰腺炎 (CP) 患者怀孕结果的遗传因素尚不清楚.
- 这项研究研究了基因突变对关键CP敏感性基因对妊娠结果的影响.
研究的目的:
- 为了评估临床特征,CP敏感性基因突变 (SPINK1,PRSS1,CTRC,CFTR) 和中国CP患者怀孕结果之间的关联.
- 为了确定这群人群中不良妊娠结果的危险因素.
主要方法:
- 展望性队列研究,随访14年.
- 包括已记录怀孕和已知的遗传背景的女性CP患者.
- 使用单变体和多变体分析,比较了具有和没有基因突变的患者之间的不良妊娠结果.
主要成果:
- 在160名注册的CP女性患者中,59.4%携带了CP敏感性基因的致病突变.
- 有基因突变的患者 (30.5%) 与没有基因突变的患者 (13.8%,P=0.015) 相比,不良妊娠结果更为普遍.
- SPINK1突变与更高的早产率 (12.6%与3.1%) 和堕胎率 (17.9%与4.6%) 有关. CP敏感性基因突变 (OR,2.52;P=0.033) 和SPINK1突变 (OR,2.60;P=0.037) 独立增加了不良结果的风险. 怀孕期间的急性疼痛发作也构成了风险.
结论:
- 在慢性胰腺炎患者中,CP敏感性基因的致病突变,特别是SPINK1,独立地与不良妊娠结果有关.
- 患有CP敏感性基因突变的孕妇需要提高临床注意力.
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