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Updated: Jul 4, 2025

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Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

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通过PROTAC介导的NR4A1降解作为癌症免疫治疗的新策略

Lei Wang1, Yufeng Xiao2, Yuewan Luo1

  • 1Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.

The Journal of experimental medicine
|February 9, 2024
PubMed
概括

一种新的癌症疗法通过降解NR4A1,这是维持免疫抑制的关键分子,以向瘤微环境. 这种方法使用一种名为NR-V04的蛋白质溶解向嵌合体 (PROTAC),有望增强抗癌免疫反应.

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