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减肥手术后的长期大脑结构和认知
Emma Custers1,2, Debby Vreeken1,2, Robert Kleemann3
1Department of Medical Imaging, Anatomy, and Radboud Alzheimer Center, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands.
JAMA network open
|February 9, 2024
概括
减肥手术改善了肥胖成年人的认知能力和整体健康状况,手术后两年. 该程序还改变了大脑血管效率和皮质厚度,为肥胖和痴呆症患者提供了潜在的好处.
科学领域:
- 神经科学是一个神经科学.
- 腹部外科 腹部外科
- 肥胖问题研究研究
背景情况:
- 减肥手术 (BS) 会导致减肥,影响认知和大脑结构.
- 之前的研究队伍小,随访时间短,限制了对长期神经效应的理解.
研究的目的:
- 研究BS后减肥对认知,大脑结构和 perfusion 的长期影响.
- 为了评估认知表现的变化,大脑体积,皮质厚度和脑血流量在手术后长达两年的时间.
主要方法:
- 一项队列研究涉及133名患有严重肥胖症的参与者,他们接受了Roux-en-Y胃旁路术.
- 在手术前和6个月和24个月收集的数据,包括认知测试,脑成像和健康标志物.
- 分析的重点是认知功能,大脑结构,大脑血流和一般健康指标的变化.
主要成果:
- 在BS.24个月后,42.9%的参与者在全球认知上至少有20%的改善.
- 观察到炎症标志物,抗高血压药物使用和抑郁症状的显著减少.
- 虽然大多数大脑区域显示结构和 perfusion 减少,海马和白质保持稳定;皮层厚度增加,其空间变化系数下降.
结论:
- 腹部外科手术在手术后两年与显著的认知和整体健康改善有关.
- 手术对大脑血管效率和皮质结构产生了积极的影响.
- 这些发现表明BS可能是肥胖患者的有价值的治疗选择,可能会减轻与痴呆症相关的风险.
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