与健康受试者相比,双极性障碍各个阶段的神经认知
Elvan Ciftci1, Shams Farhad2, Baris Metin3
1Department of Psychiatry, NP Istanbul Brain Hospital, Uskudar University, Istanbul, Turkey.
Cognitive neuropsychiatry
|February 9, 2024
概括
双相情绪障碍 (BD) 的认知障碍在所有情绪状态中持续存在,包括euthymia. 这些神经认知缺陷甚至在缓解期间也存在,影响整体功能.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 双极性障碍 (BD) 的特点是认知异常.
- 这些缺陷可能会在安乐死症期间持续存在,并且与职业表现不佳有关.
- 了解跨BD阶段的认知差异至关重要.
研究的目的:
- 评估双极性障碍阶段之间的神经认知参数差异.
- 为了比较BD患者与健康个体的认知功能.
主要方法:
- 一项对169名BD患者 (躁狂,抑郁,混合,性阶段) 和45名健康对照者的横截面研究.
- 评估工作记忆,人脸识别,执行功能和视觉/语言记忆.
- 使用Kruskal-Wallis和Mann-WhitneyU测试进行分析.
主要成果:
- 在所有测试的神经认知领域中,BD患者表现出损伤.
- 在两极性障碍不同阶段之间没有发现显著的认知差异.
- 在BD的认知表现在很大程度上独立于当前的情绪状态.
结论:
- 双相情感障碍的认知功能障碍即使在缓解期间也存在.
- 在BD中神经认知缺陷似乎是一个持久的特征,无论疾病的阶段如何.
- 研究结果表明,需要针对BD患者的持续认知障碍进行干预.
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