可穿戴的生物粘合超声波剪切波弹性图形
Hsiao-Chuan Liu1,2, Yushun Zeng3, Chen Gong3
1Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Science advances
|February 9, 2024
概括
可穿戴式超声波弹性图 (BAUS-E) 能够持续监测急性肝衰竭 (ALF) 的肝硬度. 这项创新可以在几个小时内早期检测到关键变化,从而改善患者的治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 医疗成像医学成像
- 肝病学 肝病学是一种肝病学.
背景情况:
- 急性肝衰竭 (ALF) 是一种严重的疾病,需要持续监测.
- 由于探头的要求,传统的超声波弹性学缺乏持续监测能力.
- 早期发现肝功能障碍对于及时干预至关重要.
研究的目的:
- 推出一种新的可穿戴生物粘合超声波弹性图形 (BAUS-E) 系统.
- 为了使肝硬性的持续,非侵入性监测.
- 评估BAUS-E用于检测ALF诱导的变化的可行性.
主要方法:
- 开发一个紧的128通道可穿戴生物粘合超声波弹性图形 (BAUS-E) 装置.
- 使用声波辐射力脉冲 (ARFI) 产生剪切波用于硬度测量.
- 在体内监测大鼠肝脏与d-银胺诱导的ALF超过48小时.
主要成果:
- BAUS-E成功实现了对肝硬度的持续监测.
- 在ALF诱导后的前6小时内检测到显著的硬度变化.
- 可穿戴设备展示了舒适的可穿戴性和紧的设计.
结论:
- 可穿戴生物粘合超声波弹性图 (BAUS-E) 是持续监测肝硬性的有前途的工具.
- BAUS-E有助于早期发现急性肝衰竭.
- 潜在的临床应用包括移植后和ICU患者监测.
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