斯特罗姆衍生MAOB促进前列腺癌的生长和进展
Tianjie Pu1, Jing Wang1, Jing Wei1
1Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.
Science advances
|February 9, 2024
概括
在前列腺癌中,单胺氧化酶B (MAOB) 促进瘤生长和进展. 在肌肉中抑制MAOB为前列腺癌提供了潜在的治疗策略.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 前列腺癌 (PC) 的进展受到瘤微环境的影响.
- 在PC微环境中的流体细胞在调节瘤生长方面发挥着至关重要的作用.
- 了解流体贡献是开发新型治疗策略的关键.
研究的目的:
- 为了研究单胺氧化酶B (MAOB) 在前列腺癌中所扮演的角色.
- 确定MAOB水平与PC患者的临床结果之间的关联.
- 探索MAOB作为前列腺癌的潜在治疗点.
主要方法:
- 在人类PC流体中量化MAOB水平.
- 在体外研究中,涉及前列腺 stromal 纤维细胞中MAOB的淘汰/过度表达.
- 共同培养和体内老鼠异种移植模型来评估瘤生长.
- 信号通路的分析,包括活性氧物种,CXCL12/CXCR4和TGFβ1.1.
主要成果:
- 在PC侧膜瘤中MAOB水平升高与不良的临床结果相关.
- 在 stromal 细胞中的 MAOB 增强了 PC 细胞的增殖,迁移,入侵和瘤生长.
- 通过ROS生产和ECM重塑,MAOB诱导了一个原始源的反应性层体.
- 瘤中MAOB对CXCL12进行上调,从而激活瘤CXCR4信号传递.
结论:
- 前列腺层瘤中MAOB显著促进前列腺癌的进展.
- 通过特定的分子机制,MAOB促进原始原生微环境.
- 药理上抑制 stromal MAOB 有效地限制了PC异种植的生长.
- MAOB代表了前列腺癌的一个有前途的基层治疗标.
更多相关视频
08:54Generation of Tumor Organoids from Genetically Engineered Mouse Models of Prostate Cancer
Published on: June 13, 2019
10.6K
11:15A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
10.2K
相关概念视频
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Cancer Stem Cells and Tumor Maintenance
4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K
Mesenchymal Stem Cells
4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K
