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Updated: Jul 4, 2025

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

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在Trp53;p16缺乏的小鼠中NRF2激活驱动口腔状细胞癌

Samera H Hamad1,2,3, Rani S Sellers1,4, Nathan Wamsley5

  • 1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.

Cancer research communications
|February 9, 2024
PubMed
概括

构成性激活NRF2 (NFE2L2) 转录因子驱动口腔状细胞癌 (OSCC) 在缺乏p53和p16瘤抑制剂的小鼠中. 这种新型号模仿了人类的HNSCC基因,有助于OSCC的研究.

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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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