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Updated: Jul 4, 2025

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
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Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

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组合MCP-Mod用于两种药物组合剂量范围研究

Yifan Zhou1, Abigail Sloan1, Sandeep Menon1

  • 1Pfizer Research and Development, Pfizer Inc, Cambridge, Massachusetts, USA.

Journal of biopharmaceutical statistics
|February 9, 2024
PubMed
概括

这项研究介绍了组合MCP-Mod,这是优化两种药物组合疗法的新方法. 它有效地确定最佳剂量,改善药物开发时间表和临床试验中的疗效.

关键词:
这就是MCP-Mod.组合疗法治疗组合治疗.确定剂量的方法.剂量-反应关系概念证明的概念证明目标剂量的目标剂量.

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