怀孕期间母亲状况与头周和自闭症谱系障碍的相关性分析:一种倾向性得分匹配的研究
1Department of Burns and Plastic Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, People's Republic of China.
Medicine
|February 9, 2024
概括
孕妇在怀孕期间补充叶酸 (FA) 与子女患自闭症谱系障碍 (ASD) 和异常头周 (HC) 的风险较低有关. 这表明FA可能在神经发育中起着保护作用.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿科卫生保健 儿科卫生保健
- 孕产妇健康 孕产妇健康
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况.
- 在一些患有自闭症的儿童中观察到异常的头周 (HC),包括大脑和小脑.
- 母亲的健康状况和产前因素越来越被认为是对ASD风险的潜在影响.
研究的目的:
- 调查怀孕期间母亲的健康状况与后代患ASD和异常HC的风险之间的联系.
- 检查在怀孕期间补充叶酸 (FA) 与ASD和HC结局有关的特定作用.
主要方法:
- 观察性病例控制研究设计.
- 包括被诊断患有自闭症的汉族儿童和典型的发展 (TD) 控制.
- 倾向性得分匹配和多变量逻辑回归分析以控制混因素.
- 通过物理测量和有关风险因素和FA补充的母亲问卷收集数据.
主要成果:
- 与TD对照组相比,ASD儿童的大脑 (22.0%对1.8%) 和小脑 (17.1%对1.8%) 的发病率明显较高.
- 怀孕期间母亲的FA补充与ASD (OR=3.69) 和异常高血压 (大脑:OR=8.13;小脑:OR=4.16) 的风险降低显著相关.
- 在ASD组中,异常HC的总发病率高于TD组.
结论:
- 异常的头周长在患有自闭症的儿童中更为普遍.
- 孕妇在怀孕期间补充叶酸可能会对后代发展ASD和异常HC产生保护作用.
- 需要进一步研究母亲的健康状况及其对ASD病因学的影响.
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