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Updated: Jul 4, 2025

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
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ERBB2-放大叶状乳腺癌同时表现出CDK12联合放大,与预后不佳的特征相关

Miriam Forster-Sack1, Martin Zoche1, Bernhard Pestalozzi2,3

  • 1Department of Pathology and Molecular Pathology, University Hospital Zurich, Zürich, Switzerland.

The journal of pathology. Clinical research
|February 9, 2024
PubMed
概括

扩大ERBB2的侵袭性叶状乳腺癌 (ILBC) 是一个独特的亚型,具有攻击性特征和频繁的CDK12联合增强. 这种分子子组与预后不佳和对HER2向疗法的耐药性有关.

关键词:
在ERBB2/CDK12协同放大过程中,ERBB2/CDK12协同放大.球状ERBB2突变的突变额叶性癌瘤 (lobular carcinoma) 是一种癌症.预后不好,预后不好.

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