凝微针具有编程的中相过渡,用于控制药物输送
Hala Dawud1, Nicole Edelstein-Pardo2,3,4, Keerthana Mulamukkil2,3,4
1Department of Pharmaceutical Engineering, Azrieli College of Engineering Jerusalem, Jerusalem 9103501, Israel.
ACS applied bio materials
|February 9, 2024
概括
研究人员开发了新型的水凝微针,使用两动物进行最少的侵入性药物输送. 这些微针表现出机械强度,可控制药物释放,并有效地穿透皮肤,以改善治疗结果.
科学领域:
- 生物材料工程 生物材料工程
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 基于微针的药物输送绕过了皮肤屏障,用于最少的侵入性管理.
- 水凝微针可以精确控制治疗剂的释放.
- 对于微针制造,研究了具有酶可切割的疏水性末端组的triblock两生物.
研究的目的:
- 为了研究从triblock两动物中制造水凝微针.
- 为了提高微针的机械性能,使用酸基和聚合物辅料.
- 评估这些微针在插入效率,机械强度,药物释放和皮肤透方面的性能.
主要方法:
- 微针的制造使用triblock两,聚乙烯糖醇 (PEG) 和树突侧块.
- 优化微针配方与藻酸盐和聚合物辅助剂.
- 机械强度测试使用静态力和Parafilm作为皮肤模型.
- 在体外药物释放研究中,使用德甲 (DEX) 作为模型药物.
- 使用皮进行体内插入试验.
主要成果:
- 优化的微针显示出良好的插入效率和机械强度.
- 微针迅速膨胀成水凝,并通过酶分解成可溶性聚合物.
- 甲释放跟随第一阶动力学,其中90%在6天内释放.
- 微针在的皮肤插入试验中显示出完全的透.
结论:
- 从triblock两动物制造的形成水凝的微针是可行的.
- 这些微针具有可调节的特性,可控制药物释放和有效的皮肤输送.
- 开发的系统显示了自我管理的潜力,改善了患者的遵从性,并提高了治疗疗效.
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