微塑料在人类胆结石中被检测到,并且有能力形成大型胆固醇-微塑料异质聚合物
Deyu Zhang1, Chang Wu1, Yue Liu1
1Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Journal of hazardous materials
|February 9, 2024
概括
微塑料存在于人类的胆结石中,特别是在年轻患者中,并且可以通过与胆固醇相互作用和改变肠道细菌来加速胆结石的形成. 这项研究强调了微塑料污染对健康的风险.
科学领域:
- 环境健康 环境健康
- 胃肠病学 胃肠病学
- 毒理学 毒理学 毒理学
背景情况:
- 微塑料污染无处不在,进入食物链并对人类健康构成风险.
- 胆结石 (胆结石) 是一种常见的疾病,其形成机制尚未完全理解.
- 环境污染物如微塑料在加剧胆结石疾病中的作用需要研究.
研究的目的:
- 为了检测人类胆结石中的微塑料.
- 阐明微塑料促进胆病的机制.
- 评估微塑料对肠道微生物群组成的影响.
主要方法:
- 16名患者的胆结石使用激光直接红外和热解气体染色学-质谱学分析了微塑料.
- 用了一种胆结石形成的小鼠模型,小鼠接触到不同尺寸的微塑料 (0.5,5,50微米).
- 通过共同培养和分子动力学模拟测试了微塑料-胆固醇/bilirubin亲和力;使用16S rRNA测序分析了肠道微生物群.
主要成果:
- 在所有患者的胆结石中都确认了微塑料,在年轻人 (<50岁) 中度更高.
- 与高胆固醇饮食同时接触微塑料的小鼠表现出更严重的胆固醇病变.
- 微塑料对胆固醇的亲和力比胆红素更大,在小鼠中观察到显著的肠道微生物群变化.
结论:
- 微塑料存在于人类的胆结石中,可以加剧胆病.
- 微塑料可能通过产生胆固醇-微塑料异质聚合物来促进胆结石的形成.
- 摄入微塑料会改变肠道微生物群,可能导致胆结石疾病的进展.
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