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电子喷雾技术为多颗粒物制备的最新进展:药物输送应用

Mulham Alfatama¹, Yasser Shahzad², Hazem Choukaife¹

¹Faculty of Pharmacy, Universiti Sultan Zainal Abidin, Besut Campus, Besut 22200, Terengganu, Malaysia.

Advances in colloid and interface science

|February 9, 2024

概括

电子喷雾 (ES) 是一种多功能技术,用于创建量身定制的药物输送载体. 优化实验参数允许精确控制粒子特征,如大小和形态,以有效封装治疗剂.

科学领域:

材料科学材料科学材料科学
生物医学工程生物医学工程
制药科学制药科学

背景情况:

电喷射 (ES) 技术为制造药物输送载体提供了一个多功能平台.
定制载体尺寸,层和形态对于有效的药物输送至关重要.

研究的目的:

审查用于制造药物输送载体的电喷系统配置.
检查影响ES过程和粒子特征的关键参数.
突出ES对各种治疗剂的封装能力.

主要方法:

对普遍存在的ES系统配置 (单轴,同轴,三轴,多针) 的审查.
分析关键的实验参数:聚合物选择,表面张力,电压,针尺寸,流量,收集器类型和距离.
检查对粒子形态,大小分布和封装效率的影响.

主要成果:

能精确控制药物输送载体的特性.
不同的ES配置和参数显著影响粒子特性.
ES有效地封装了广泛的治疗剂,包括药物,核酸,蛋白质,基因和细胞.

结论:

电子喷雾是一种高度适应的技术,用于设计定制的药物输送系统.
优化ES参数对于实现所需的载体特性和封装效率至关重要.
本综述提供了关于ES优化策略,优势,局限性以及药物输送的未来方向的指导.

关键词:

药物输送是药物输送的过程.电动力学原子化电气化.电子喷雾剂是一种电子喷雾剂.微粒微粒的使用方法纳米颗粒纳米颗粒

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