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Updated: Jul 4, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

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通过点击化学构建三醇修饰的奇纳林衍生物作为选择性的c-MYC G-四重复合联体和强大的抗癌剂

Jiong-Heng Cai1, Dan-Yan Yang1, Jun-Jie Zhang1

  • 1School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou 510006, China.

Bioorganic chemistry
|February 9, 2024
PubMed
概括

研究人员开发了新的三醇修饰的奇纳 (TMQ) 衍生物,可以稳定c-MYC G-quadruplex (G4) 结构. 化合物A6选择性地抑制c-MYC转录并抑制癌细胞的进展,提供了一个有前途的治疗策略.

关键词:
这是一种抗癌药物.点击 化学 点击 化学 .在G-quadruplex中使用.基纳氨酸氨酸是什么c-MYC转录的转录方式

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