一个三叶子因子3-Lingo2轴在肠道线虫感染期间抑制1型T型辅助细胞的增殖扩张
Lucas M Ethgen1, Christopher Pastore2, Cailu Lin3
1Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Mucosal immunology
|February 9, 2024
概括
研究表明,肠道三叶草因子 (TFF3) 控制T辅助细胞平衡,促进对寄生虫虫的免疫力. 删除它的受体会损害T辅助细胞2的发育,有利于T辅助细胞1并阻碍寄生虫的驱逐.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 类动物学 类动物学
背景情况:
- 粘膜表面的宿主防御涉及复杂的细胞相互作用.
- 像TFF3一样,三叶草因子家族 (TFF) 对于受伤后的上皮质修复至关重要.
- 在感染期间指导免疫细胞功能时,TFF及其受体的作用尚不清楚.
研究的目的:
- 调查肠道三叶子因子3 (TFF3) 在调节寄生虫线虫感染期间免疫细胞反应中的作用.
- 确定TFF3及其受体LINGO2是否会影响T辅助细胞子集 (TH1/TH2) 的平衡.
主要方法:
- 使用了Trichuris muris感染的小鼠模型.
- 生成的T细胞特异性淘汰赛小鼠缺乏TFF3受体,LINGO2.
- 分析了T辅助细胞的增殖,分化 (TH1/TH2平衡) 和干扰素- (IFN-γ) 生产.
主要成果:
- 发现TFF3抑制了T助手1 (TH1) 细胞的增殖,并促进了对Trichuris muris的2型免疫力.
- 特定于T细胞的LINGO2 (TFF3受体) 缺失导致TH2细胞承诺受损.
- LINGO2 除导致 IFN-γ+ CD4+ TH1 细胞增加,并通过依赖 IFN-γ 的通路阻止了虫的驱逐.
结论:
- 在粘膜免疫中,TFF3发挥着双重作用,有助于组织修复和抗虫免疫.
- TFF3调节TH1和TH2细胞子集之间的平衡,这对于对寄生虫感染有效的宿主防御至关重要.
- 针对TFF3-LINGO2轴可以为虫感染和免疫媒介疾病提供治疗策略.
相关概念视频
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
Renewal of Intestinal Stem Cells
2.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Pleiotropy
40.4K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
40.4K
TGF - β Signaling Pathway
7.4K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.4K


