鼻内药物输送:纳米粒子与鼻到脑通路之间的相互作用
Yaoxing Chen1, Chenyun Zhang1, Yukun Huang1
1Department of Pharmacology and Chemical Biology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Universities Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
鼻内输送使用纳米颗粒将药物直接运送到大脑,绕过血脑屏障. 本综述探讨了纳米颗粒与鼻至大脑通路的相互作用,以改善神经系统疾病的脑药物输送.
科学领域:
- 药理学 药理学是指药理学的学科.
- 纳米技术纳米技术
- 神经科学是一个神经科学.
背景情况:
- 鼻内输送提供了直接的,非侵入性的通道到中枢神经系统.
- 纳米粒子是提高大脑药物递送效率的关键载体.
- 了解纳米粒子-大脑通路相互作用对于优化交付至关重要.
研究的目的:
- 审查鼻至大脑通路的特征和障碍.
- 在这个路径中概述纳米粒子相互作用.
- 讨论用于鼻至脑药物输送的纳米颗粒系统.
主要方法:
- 综合文献综述. 这是一个全面的文献综述.
- 分析鼻至大脑通路的解剖和生理特征.
- 对纳米颗粒药物输送系统的评估.
主要成果:
- 详细概述鼻至大脑通道及其固有的障碍.
- 探索纳米颗粒如何与大脑向的鼻腔通路相互作用.
- 对各种纳米颗粒系统的概述,应用于鼻至大脑输送.
结论:
- 基于纳米颗粒的鼻内输送对治疗大脑疾病具有重大前景.
- 对纳米粒子-大脑相互作用的进一步研究可以优化药物递送效率.
- 本综述为开发先进的鼻至脑治疗策略提供了见解.
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