在中年老鼠中,Centella asiatica通过控制氧化应激和胆性传播来改善记忆和执行功能
Zeba Firdaus1, Gopichand Gutti2, Ankit Ganeshpurkar2
1Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Journal of ethnopharmacology
|February 9, 2024
概括
亚洲 (CAE) 的乙醇提取物通过其抗氧化和抗胆固醇作用提供神经保护,从而逆转老年相关的老鼠认知衰退.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 老年学是一门学科.
背景情况:
- 亚洲 (Centella asiatica) 是一种用于认知增强的传统药用草本.
- 老龄化导致生物衰变,特别是影响大脑中的认知功能.
研究的目的:
- 评估Centella asiatica (CAE) 乙醇提取物对老年相关认知障碍在老鼠中的有效性.
- 阐明CAE对认知功能的作用的潜在机制.
主要方法:
- 中年老鼠在42天内接受了不同度的CAE (150,300,450毫克/公斤) 治疗.
- 行为测试 (Y迷宫,开放场,新型物体识别,升高加迷宫) 评估认知表现.
- 生物化学测试 (MDA,SOD,ACHE) 和H&E染色评估了大脑的变化;HPLC和体外/in silico研究分析了CAE的特性.
主要成果:
- CAE治疗改善了行为表现,并减少了与年龄相关的MDA,SOD和ACHE活动的增加.
- 神经元损失减弱,CAE在体外表现出度依赖的抗氧化剂和抗乙胆酶 (AChE) 活性.
- 在CAE中,亚洲酸和马德卡斯酸与胆固醇酶具有良好的结合,表明有抗胆固醇作用.
结论:
- 由于CAE的抗胆固醇和抗氧化特性归因于亚洲酸和马德卡斯酸,有效地对抗与年龄相关的认知衰退.
- CAE不仅可以保护,还可以逆转与衰老相关的认知障碍.
- 这项研究验证了Centella asiatica在老化模型中的神经保护潜力.
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