尿液微生物和预测性基因组概况与精子参数异常有关:对男性次生育能力的影响
Vadim Osadchiy1, Andre Belarmino1, Reza Kianian1
1Division of Andrology, Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
F&S science
|February 9, 2024
概括
尿液微生物组在具有异常精液参数的男性中不同,特别是精子运动性. 特定的细菌和功能途径可能会影响精子健康,为男性生育能力提供见解.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生殖医学 生殖医学
背景情况:
- 人类微生物组在健康和疾病中起着至关重要的作用.
- 了解尿路微生物组与男性生殖健康之间的关系是一个新兴的研究领域.
- 精液分析参数的变化可以显著影响男性生育能力.
研究的目的:
- 为了研究尿液微生物组和精液分析 (SA) 参数之间的分类学和功能关系.
- 识别与异常精子参数相关的特定微生物特征.
- 探索可能的功能机制,将尿液微生物组与精子质量联系起来.
主要方法:
- 在一个学术医疗中心进行的截面研究.
- 招募男性进行生育能力评估或输精管切除咨询.
- 根据正常或异常的精液分析参数对参与者的分层.
- 分析尿液微生物群的分类学和功能概况.
主要成果:
- 在有异常精子运动性的男性中,Dialister micraerophilus的丰度增加了近50倍.
- 在精子度异常的男性中,Enterococcus faecalis和Staphylococcus aureus的丰度较低.
- 精子运动能力受损的男性的尿液微生物组功能概况显示氧化-减氧平衡和细胞寿命途径的显著差异.
结论:
- 具有异常精液参数的男性的尿道微生物组存在显著差异,特别是精子运动性.
- 这项研究突出了影响精子参数的潜在微生物和功能机制.
- 这些发现有助于更好地了解尿路微生物组与男性生育能力之间的相互作用.
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