口腔感染Porphyromonas gingivalis增强的牙上皮质屏障分子随着年龄的增长而变化
Sarita Giri1, Ayuko Takada2, Durga Paudel3
1Division of Periodontology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan.
Journal of oral biosciences
|February 9, 2024
概括
老龄化和 Porphyromonas gingivalis 感染会削弱牙上皮屏障. 这种与年龄相关的障碍功能障碍增加了对牙周病原体的易感性,导致更大的骨质损失.
科学领域:
- 牙周病学 牙周病学
- 衰老研究研究 衰老研究
- 皮质生物学 皮质生物学
背景情况:
- 牙上皮质屏障的完整性对口腔健康至关重要.
- 老化和 Porphyromonas gingivalis 是已知的破坏者 这一障碍.
- 对屏障分子的综合作用需要进一步研究.
研究的目的:
- 研究衰老和P. gingivalis对牙上皮质屏障功能的协同影响.
- 在这些条件下分析关键结点分子的变化.
- 评估对膜骨损失和炎症的后果.
主要方法:
- 在体外研究中使用了与P. gingivalis脂多糖 (LPS) 治疗的老年和年轻人牙上皮原生细胞.
- 在体内研究中使用了暴露于P. gingivalis的年轻和老老鼠,评估了屏障分子,骨损失和细胞因子.
- 使用定量实时PCR,西方涂抹和免疫组织化学分析结点分子.
主要成果:
- 用LPS治疗的衰老细胞显示屏障抵抗性降低,透性增加.
- 在衰老细胞中观察到克劳丁-1和克劳丁-2的上调和E-cadherin和Connexin的下调.
- 与其他群体相比,感染P. gingivalis的老年小鼠表现出加剧的膜骨损失.
结论:
- 衰老显著改变牙上皮质屏障分子,增加对牙周病原体的敏感性.
- 结合老化和P. gingivalis感染导致明显的障碍障碍和骨质损失.
- 这些发现凸显了牙周病发病因的年龄相关脆弱性.
相关概念视频
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:26Aging
51
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
51
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:26Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K