血液恶性病患者对COVID-19疫苗的血清反应:一项前性队列研究
Alexandra Hillyer1, Anthony Quint2, Artin Ghassemian3
1Department of Medicine, University of Toronto, Toronto, ON.
Clinical lymphoma, myeloma & leukemia
|February 9, 2024
概括
在患有血液癌症的患者中,COVID-19疫苗接种会引起较弱的抗体反应. 诸如年龄,癌症类型和治疗状态等因素显著影响免疫对疫苗的反应.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 患有血液癌症的患者面临COVID-19的更高风险.
- 这些患者往往对疫苗的反应减弱.
- 了解这种群体的疫苗有效性至关重要.
研究的目的:
- 评估患有血液性恶性瘤的个体对COVID-19疫苗接种的纵向幽默性免疫反应.
- 为了确定影响疫苗有效性的因素,在这个弱势群体.
主要方法:
- 从2021年3月到2022年7月进行的前性队列研究.
- 涉及的患者年龄在18岁以上,被诊断患有血液性恶性瘤,接受COVID-19疫苗.
- 在加拿大癌症治疗中心收集样本和临床数据.
主要成果:
- 随着疫苗剂量 (V1:0.0,V2:64.0,V3:680.5U/mL) 的增加,抗S抗体标位的中位数增加.
- 与V2和V3后的髓性患者相比,淋巴细胞恶性病患者的反应减弱.
- 积极治疗与显著较低的抗体标位相关;年龄和抗CD20疗法影响了反应.
结论:
- 血液性恶性瘤患者对COVID-19疫苗接种有减弱的血清反应.
- 免疫反应受患者年龄,癌症诊断,治疗状态和相对于治疗的时间的影响.
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