住院后的全身炎症指数预测了严重烧伤患者的住院死亡率
Fuying Li1, Quanyong He1, Hao Peng1
1Department of Burns and Plastic Surgery, the third Xiangya Hospital, Central South University, Changsha, China.
Burns : journal of the International Society for Burn Injuries
|February 9, 2024
概括
综合血清衍生的炎症指标,特别是1日的淋巴细胞-血小板比率 (LPR) 和3日和7日的中性粒细胞-血小板比率 (NLPR),可靠地预测广泛烧伤患者的预后. 将这些与烧伤预后得分相结合,可以提高预测准确度.
科学领域:
- 关键护理医学 关键护理医学
- 烧伤伤害研究研究
- 炎症生物标志物 炎症生物标志物
背景情况:
- 广泛的烧伤会引发全身炎症,这是患者结果的关键因素.
- 预测烧伤患者的死亡率对于及时干预至关重要.
- 完全血清 (CBC) 衍生的指数提供可访问的炎症标志物.
研究的目的:
- 评估各种CBC衍生炎症指标的临床实用性,以预测广泛烧伤患者的住院死亡率.
- 为了确定特定的炎症标志物和时间点在预后预测中最有效.
主要方法:
- 系统性炎症指数计算,包括LPR,NLR,NMR,MLR,NLPR,SII和SIRI在接收后的1,3和7天.
- 通过多变量逻辑回归和卡普兰-梅尔生存分析分析了135名严重烧伤患者 (97名幸存者,38名未幸存者) 的数据.
主要成果:
- 第1天的淋巴细胞-血小板比率 (LPR) 和第3天和第7天的中性细胞-淋巴细胞-血小板比率 (NLPR) 与生存显著相关.
- 在第7天的NLPR显示出最高的预测准确性 (AUC=0.814).
- 将LPR和NLPR与燃烧预后得分指数相结合,显著改善了预后预测 (AUC=0.994).
结论:
- 在严重的广泛烧伤患者中,LPR (1日) 和NLPR (3日和7日) 是可靠的预后预测指标.
- 综合得分包括燃烧预后指数,LPR和NLPR,与单独燃烧指数相比,提供更高的预测效率.
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