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Updated: Jul 4, 2025

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整合功能注释与双层连续收缩,用于多基因风险预测

Yongwen Zhuang1, Na Yeon Kim2, Lars G Fritsche1

  • 1University of Michigan, Ann Arbor, USA.

BMC bioinformatics
|February 9, 2024
PubMed
概括

我们开发了PRSbils,这是一种多基因风险评分 (PRS) 的新方法,通过结合功能遗传注释和双层收缩来提高预测准确性. 这种方法通过在变体和注释层面考虑稀疏效应来提高遗传风险预测.

关键词:
生物银行数据数据持续的收缩持续的收缩功能注释功能注释通过KEGG路径.在 PRSbils 中.多基因风险评分多基因风险评分.

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