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与Shh和Nrf2一起的CTC是HNSCC的潜在诊断标志物

Md Mizanur Rahman^1,2,3, Muhammad Mosaraf Hossain^4,5, Shafiqul Islam^2,3,6

¹Rangamati Medical College, Rangamati, Bangladesh.

BMC molecular and cell biology

|February 9, 2024

概括

在头部和部状细胞癌 (HNSCC) 患者中,Sonic Hedgehog (Shh) 和核因子红色素2相关因子2 (Nrf2) 以及循环瘤细胞 (CTC) 的更高表达显示出早期诊断和预后的前景.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

尽管死亡率高,但头部和部状细胞癌 (HNSCC) 缺乏用于早期检测的有效预后生物标志物.
核因子红色素2相关因子2 (Nrf2) 和Sonic Hedgehog (Shh) 与包括HNSCC在内的各种癌症有关,是潜在的治疗点.
循环瘤细胞 (CTC) 正在成为癌症攻击性和生存结果的指标.

研究的目的:

研究Shh/Nrf2过度表达和CTC作为HNSCC的早期诊断和预后标记物的潜力.
在HNSCC患者中探索Shh/Nrf2表达和CTC之间的关系.

主要方法:

分析了151名HNSCC患者的队列,分为CTC阳性和CTC阴性组.
人口统计,临床病理特征和生存数据被收集和分析.
使用定量逆转录聚合酶链反应 (qRT-PCR) 来量化Shh和Nrf2表达水平.

主要成果:

与CTC阴性患者相比,CTC阳性HNSCC患者在血液和组织中显示出Shh/Nrf2的显著过度表达.
在CTC和人口统计/临床病理学因素之间观察到显著的关联,包括吸烟,使用白菜叶和各种血细胞计数 (红细胞,血小板,中性细胞,MCV,NLR,MLR).
化疗降低了HNSCC患者的CTC频率,较高的CTC计数与较差的整体存活率相关.

结论:

在HNSCC患者中检测循环瘤细胞 (CTC) 是一种可行的诊断和预后方法.
在HNSCC患者血液中增加的Shh和Nrf2表达是诊断和预后的有希望的生物标志物.

关键词:

在CTC中,使用CTC.癌症癌症癌症癌症在HNSCC中,我们可以看到HNSCC.Nrf2 没有任何问题.什什什什什什什这是一个很棒的体验.

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