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周围和随后的抑郁和焦虑障碍风险:使用英国生物银行进行的一项前性队列研究
Xiaowan Chen1,2,3,4, Dang Wei2, Fang Fang2
1Department of Otolaryngology Head and Neck Surgery, the First Hospital of Lanzhou University, Lanzhou, Gansu Province, China.
BMC medicine
|February 9, 2024
概括
外周 significantly增加患抑郁症和焦虑症的风险,特别是在住院后两年内. 抑郁症与大脑白质完整性降低有关.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 周围经常与精神疾病同时发生.
- 以前的研究缺乏对外围和精神疾病风险的纵向数据.
- 额外边缘网络中的白质完整性与这种并发症之间的关系尚未被探索.
研究的目的:
- 纵向评估外周后出现抑郁和焦虑障碍的风险.
- 用MRI研究外围,抑郁,焦虑和白质完整性之间的关联.
主要方法:
- 英国生物银行对452,053名参与者的队列研究 (2006-2021).
- 考克斯的比例危险模型评估了外围的住院后精神疾病风险.
- 多变量线性回归检查了36 087名参与者的MRI分数异性变异 (FA) 与异性变异的关联.
主要成果:
- 住院外围的诊断增加了抑郁症 (HR 2.18) 和焦虑症 (HR 2.11) 的风险.
- 这些风险在住院后2年内最高 (抑郁症HR 2.91,焦虑症HR 4.92).
- 抑郁症与白质区域较低的FA相关;外围和焦虑症没有显示出显著的FA关联.
结论:
- 周围与随后的抑郁和焦虑风险增加有关,特别是在两年内.
- 抑郁症与微观结构连接性和完整性降低有关,特别是在前边缘网络之外.
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