在鹿特丹研究中,AGE-RAGE轴与慢性肺病和吸烟有关
Tianqi Lu1,2, Lies Lahousse2,3, Sara Wijnant4,2,3
1Department of Internal Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015GD, Rotterdam, The Netherlands.
Respiratory research
|February 9, 2024
概括
皮肤高级糖化终产品 (AGEs) 与COPD的流行和严重程度有关,特别影响COPD患者的肺功能. 吸烟显著影响这些关联,因此需要进一步研究它们的相互作用.
科学领域:
- 肺部医学 肺部医学
- 生物标志物 生物标志物
- 衰老研究研究 衰老研究
背景情况:
- 慢性阻塞性肺病 (COPD) 和喘对全球发病率和死亡率做出了重大贡献.
- 在COPD患者中观察到高水平的先进糖化终产物 (AGEs),但其具体作用尚不清楚.
研究的目的:
- 调查皮肤自光 (SAF) 测量AGE与COPD和喘的患病率,严重程度和肺功能之间的联系.
- 探索吸烟对这些关联的影响.
主要方法:
- 分析了鹿特丹研究队列 (n=2577).
- 测量了AGE的皮肤自光 (SAF),FEV1和扩散能力 (DLCO).
- 用对共变量调整的逻辑和线性回归模型来评估关联,然后进行相互作用和分层分析.
主要成果:
- SAF显示与COPD患病率存在关联,但在调整吸烟后,这种影响减弱了.
- SAF与预测FEV1%的降低,DLCO和GOLD阶段的增加有关,在COPD患者中观察到更强的关联.
- 在COPD患者中,SAF和肺功能之间的关联更加明显,并且与吸烟状况相互作用.
结论:
- 皮肤AGE,COPD患病率和肺功能之间的关联被吸烟显著调节.
- 皮肤AGE与COPD严重程度和肺功能有关,在COPD患者群体中影响更为突出.
- 需要进一步的研究来阐明皮肤AGE,吸烟和COPD之间的因果关系.
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