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VagiBIOM Lactobacillus可以改善阴道健康指数,在有细菌性阴道炎的绝经前妇女:一个随机对照试验
Vijitha Vivekanandan1, Zaiba Hasan Khan2, Giriprasad Venugopal2
1Biom Pharmaceutical Corporation, 2203 Industrial Blvd, Sarasota, FL, USA.
Scientific reports
|February 9, 2024
概括
这项研究表明,VagiBIOM suppositories有效地改善了细菌性阴道炎 (BV) 的女性的阴道健康. 通过增强有益的乳杆菌物种多样性,治疗降低了阴道pH值和.
科学领域:
- 微生物学 微生物学
- 妇科 妇科医生 妇科
- 妇女健康 妇女健康
背景情况:
- 细菌性阴道炎 (BV) 是一种常见的阴道失调,与不良健康结果有关.
- 使用乳酸菌种恢复健康的阴道微生物组为BV提供了潜在的治疗策略.
研究的目的:
- 为了评估VagiBIOM的疗效,一个多种乳杆菌的阴道,在改善 BV.在周围和更年期前妇女的阴道健康.
- 评估VagiBIOM对阴道pH值,,努根特分数和阴道健康指数 (VHI) 的影响.
主要方法:
- 一项随机,双盲,安慰剂控制的试点研究,涉及66名患有BV的女性.
- 干预使用VagiBIOM或安慰剂假药4周.
- 评估阴道pH值, (VAS),努根特得分,VHI和微生物组合 (16SrRNA测序).
主要成果:
- 治疗VagiBIOM显著降低了阴道pH值,和Nugent分数.
- 阴道健康指数 (VHI) 评分在干预4周后显著改善.
- 微生物组分析显示,乳酸菌多样性增加,L. hamsteri和L. helveticus被确定为VagiBIOM组中的关键物种.
结论:
- 通过恢复阴道pH值,降低Nugent分数和改善整体阴道健康,VagiBIOM假药有效缓解BV症状.
- 治疗效果归因于提高阴道乳酸菌的多样性.
- 这表明VagiBIOM作为一个有前途的干预措施,用于管理BV在近期和更年期前妇女.
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